L-glutamine | Natura Foundation (2024)

1. Roth E. Nonnutritive effects of glutamine. J Nutr. 2008 Oct;138(10):2025S-2031S.

2. Cruzat V, Macedo Rogero M, Noel Keane K, Curi R, Newsholme P. Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation. Nutrients [Internet]. 2018 Oct 23 [cited 2020 Apr 28];10(11). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266414/

3. Sacks GS. Glutamine supplementation in catabolic patients. Ann Pharmacother. 1999 Mar;33(3):348–54.

4. Miller AL. Therapeutic Considerations of L-Glutamine: A Review of the Literature. Altern Med Rev. 1999;4(4):10.

5. Amores-Sánchez MI, Medina MÁ. Glutamine, as a Precursor of Glutathione, and Oxidative Stress. Mol Genet Metab. 1999 Jun;67(2):100–5.

6. Wu G. Amino acids: metabolism, functions, and nutrition. Amino Acids. 2009 May;37(1):1–17.

7. Bak LK, Schousboe A, Waagepetersen HS. The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer. J Neurochem. 2006 Aug;98(3):641–53.

8. Zhou T, Yang Y, Chen Q, Xie L. Glutamine Metabolism Is Essential for Stemness of Bone Marrow Mesenchymal Stem Cells and Bone Homeostasis. Stem Cells Int [Internet]. 2019 Sep 12 [cited 2021 Jun 15];2019. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757285/

9. Mills EL, Kelly B, O’Neill LAJ. Mitochondria are the powerhouses of immunity. Nat Immunol. 2017 May;18(5):488–98.

10. Curi R, Newsholme P, Marzuca-Nassr G, Takahashi H, Hirabara S, Cruzat V, et al. Regulatory principles in metabolism -Then and now. Biochem J. 2016 Jun 29;473:1845–57.

11. Ardawi MS, Newsholme EA. Glutamine metabolism in lymphocytes of the rat. Biochem J. 1983 Jun 15;212(3):835–42.

12. Newsholme P. Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection? J Nutr. 2001 Sep;131(9 Suppl):2515S-22S; discussion 2523S-4S.

13. Crawford J, Cohen HJ. The essential role of L-glutamine in lymphocyte differentiation in vitro. J Cell Physiol. 1985 Aug;124(2):275–82.

14. Hesterberg RS, Cleveland JL, Epling-Burnette PK. Role of Polyamines in Immune Cell Functions. Med Sci [Internet]. 2018 Mar 8 [cited 2021 Jun 3];6(1). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872179/

15. Rogeri PS, Costa Rosa LFBP. Plasma glutamine concentration in spinal cord injured patients. Life Sci. 2005 Sep 23;77(19):2351–60.

16. Lin M-T, Kung S-P, Yeh S-L, Liaw K-Y, Wang M-Y, Kuo M-L, et al. Glutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity. World J Gastroenterol. 2005 Oct 21;11(39):6197–201.

17. Aosasa S, Mochizuki H, Yamamoto T, Ono S, Ichikura T. A clinical study of the effectiveness of oral glutamine supplementation during total parenteral nutrition: influence on mesenteric mononuclear cells. JPEN J Parenter Enteral Nutr. 1999 Oct;23(5 Suppl):S41-44.

18. Chen G, Xie W, Jiang H. [Clinical observation of the protective effect of oral feeding of glutamine granules on intestinal mucous membrane]. Zhonghua Shao Shang Za Zhi Zhonghua Shaoshang Zazhi Chin J Burns. 2001 Aug;17(4):210–1.

19. Wu G. Intestinal mucosal amino acid catabolism. J Nutr. 1998 Aug;128(8):1249–52.

20. Newsholme EA, Carrié AL. Quantitative aspects of glucose and glutamine metabolism by intestinal cells. Gut. 1994 Jan;35(1 Suppl):S13–7.

21. Ashy AA, Salleh M, Ardawi M. Glucose, glutamine, and ketone-body metabolism in human enterocytes. Metabolism. 1988 Jun;37(6):602–9.

22. Wang B, Wu G, Zhou Z, Dai Z, Sun Y, Ji Y, et al. Glutamine and intestinal barrier function. Amino Acids. 2015 Oct;47(10):2143–54.

23. Ramachandran A, Madesh M, Balasubramanian KA. Apoptosis in the intestinal epithelium: its relevance in normal and pathophysiological conditions. J Gastroenterol Hepatol. 2000 Feb;15(2):109–20.

24. Matés JM, Pérez-Gómez C, Núñez de Castro I, Asenjo M, Márquez J. Glutamine and its relationship with intracellular redox status, oxidative stress and cell proliferation/death. Int J Biochem Cell Biol. 2002 May;34(5):439–58.

25. Radtke F, Clevers H. Self-renewal and cancer of the gut: two sides of a coin. Science. 2005 Mar 25;307(5717):1904–9.

26. Yi D, Hou Y, Wang L, Ouyang W, Long M, Zhao D, et al. L-Glutamine enhances enterocyte growth via activation of the mTOR signaling pathway independently of AMPK. Amino Acids. 2015 Jan;47(1):65–78.

27. Saxton RA, Sabatini DM. mTOR Signaling in Growth, Metabolism, and Disease. Cell. 2017 Mar 9;168(6):960–76.

28. Noth R, Häsler R, Stüber E, Ellrichmann M, Schäfer H, Geismann C, et al. Oral glutamine supplementation improves intestinal permeability dysfunction in a murine acute graft-vs.-host disease model. Am J Physiol-Gastrointest Liver Physiol. 2013 Apr 1;304(7):G646–54.

29. Kim M-H, Kim H. The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases. Int J Mol Sci. 2017 May 12;18(5).

30. Rao R, Samak G. Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions. J Epithel Biol Pharmacol. 2012 Jan;5(Suppl 1-M7):47–54.

31. Veldhoen M, Brucklacher-Waldert V. Dietary influences on intestinal immunity. Nat Rev Immunol. 2012 Oct;12(10):696–708.

32. Ruth MR, Field CJ. The immune modifying effects of amino acids on gut-associated lymphoid tissue. J Anim Sci Biotechnol. 2013 Jul 30;4(1):27.

33. Alverdy JC. Effects of glutamine-supplemented diets on immunology of the gut. JPEN J Parenter Enteral Nutr. 1990 Aug;14(4 Suppl):109S-113S.

34. Wu M, Xiao H, Liu G, Chen S, Tan B, Ren W, et al. Glutamine promotes intestinal SIgA secretion through intestinal microbiota and IL-13. Mol Nutr Food Res. 2016 Jul;60(7):1637–48.

35. Kim H. Glutamine as an Immunonutrient. Yonsei Med J. 2011 Nov 1;52(6):892–7.

36. Rhoads J, Wu G. Glutamine, arginine, and leucine signaling in the intestine. Amino Acids. 2009 Feb 1;37:111–22.

37. Coëffier M, Marion R, Ducrotté P, Déchelotte P. Modulating effect of glutamine on IL-1beta-induced cytokine production by human gut. Clin Nutr Edinb Scotl. 2003 Aug;22(4):407–13.

38. Lawrence T. The Nuclear Factor NF-?B Pathway in Inflammation. Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a001651.

39. Coleman JW. Nitric oxide in immunity and inflammation. Int Immunopharmacol. 2001 Aug;1(8):1397–406.

40. Swierkosz TA, Mitchell JA, Sessa WC, Hecker M, Vane JR. L-glutamine inhibits the release of endothelium-derived relaxing factor from the rabbit aorta. Biochem Biophys Res Commun. 1990 Oct 15;172(1):143–8.

41. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci U S A. 1987 Dec;84(24):9265–9.

42. Nurjhan N, Bucci A, Perriello G, Stumvoll M, Dailey G, Bier DM, et al. Glutamine: a major gluconeogenic precursor and vehicle for interorgan carbon transport in man. J Clin Invest. 1995 Jan;95(1):272–7.

43. Perriello G, Nurjhan N, Stumvoll M, Bucci A, Welle S, Dailey G, et al. Regulation of gluconeogenesis by glutamine in normal postabsorptive humans. Am J Physiol. 1997 Mar;272(3 Pt 1):E437-445.

44. Bakalar B, Duska F, Pachl J, Fric M, Otahal M, Pazout J, et al. Parenterally administered dipeptide alanyl-glutamine prevents worsening of insulin sensitivity in multiple-trauma patients. Crit Care Med. 2006 Feb;34(2):381–6.

45. Reimann F, Williams L, da Silva Xavier G, Rutter GA, Gribble FM. Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells. Diabetologia. 2004 Sep;47(9):1592–601.

46. Gromada J, Holst JJ, Rorsman P. Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1. Pflugers Arch. 1998 Apr;435(5):583–94.

47. Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev. 2007 Oct;87(4):1409–39.

48. Leite JSM, Cruzat VF, Krause M, Homem de Bittencourt PI. Physiological regulation of the heat shock response by glutamine: implications for chronic low-grade inflammatory diseases in age-related conditions. Nutrire. 2016 Nov 3;41(1):17.

49. Hooper PL, Balogh G, Rivas E, Kavanagh K, Vigh L. The importance of the cellular stress response in the pathogenesis and treatment of type 2 diabetes. Cell Stress Chaperones. 2014 Jul;19(4):447–64.

50. Ziegler TR, Ogden LG, Singleton KD, Luo M, Fernandez-Estivariz C, Griffith DP, et al. Parenteral glutamine increases serum heat shock protein 70 in critically ill patients. Intensive Care Med. 2005 Aug;31(8):1079–86.

51. Manganese [Internet]. Linus Pauling Institute. 2014 [cited 2021 Jun 9]. Available from: https://lpi.oregonstate.edu/mic/minerals/manganese

52. Huang Y, Su L, Wu J. Pyridoxine Supplementation Improves the Activity of Recombinant Glutamate Decarboxylase and the Enzymatic Production of Gama-Aminobutyric Acid. PloS One. 2016;11(7):e0157466.

53. Nissim I. Newer aspects of glutamine/glutamate metabolism: the role of acute pH changes. Am J Physiol-Ren Physiol. 1999 Oct 1;277(4):F493–7.

54. Dejong CH, Deutz NE, Soeters PB. Ammonia and glutamine metabolism during liver insufficiency: the role of kidney and brain in interorgan nitrogen exchange. Scand J Gastroenterol Suppl. 1996;218:61–77.

55. Curthoys NP, Watford M. Regulation of glutaminase activity and glutamine metabolism. Annu Rev Nutr. 1995;15:133–59.

56. Welbourne TC. Increased plasma bicarbonate and growth hormone after an oral glutamine load. Am J Clin Nutr. 1995 May;61(5):1058–61.

57. Dasarathy S, Mookerjee RP, Rackayova V, Rangroo Thrane V, Vairappan B, Ott P, et al. Ammonia toxicity: from head to toe? Metab Brain Dis. 2017 Apr;32(2):529–38.

58. Häussinger D, Schliess F. Glutamine metabolism and signaling in the liver. Front Biosci J Virtual Libr. 2007 Jan 1;12:371–91.

59. Wagenmakers AJ. Muscle amino acid metabolism at rest and during exercise: role in human physiology and metabolism. Exerc Sport Sci Rev. 1998;26:287–314.

60. Wu G, Bazer FW, Johnson GA, Knabe DA, Burghardt RC, Spencer TE, et al. Triennial Growth Symposium: important roles for L-glutamine in swine nutrition and production. J Anim Sci. 2011 Jul;89(7):2017–30.

61. Wernerman J. Clinical Use of Glutamine Supplementation. J Nutr. 2008 Oct 1;138(10):2040S-2044S.

62. Newsholme EA, Parry-Billings M. Properties of Glutamine Release From Muscle and Its Importance for the Immune System. J Parenter Enter Nutr. 1990;14(4S):63S-67S.

63. Perna S, Alalwan TA, Alaali Z, Alnashaba T, Gasparri C, Infantino V, et al. The Role of Glutamine in the Complex Interaction between Gut Microbiota and Health: A Narrative Review. Int J Mol Sci. 2019 Oct 22;20(20):E5232.

64. Wu G, Knabe DA, Yan W, Flynn NE. Glutamine and glucose metabolism in enterocytes of the neonatal pig. Am J Physiol. 1995 Feb;268(2 Pt 2):R334-342.

65. Haisch M, Fukagawa NK, Matthews DE. Oxidation of glutamine by the splanchnic bed in humans. Am J Physiol Endocrinol Metab. 2000 Apr;278(4):E593-602.

66. Ardawi MS. Glutamine metabolism in the lungs of glucocorticoid-treated rats. Clin Sci Lond Engl 1979. 1991 Jul;81(1):37–42.

67. Parry-Billings M, Dimitriadis GD, Leighton B, Bond J, Bevan SJ, Opara E, et al. Effects of hyperthyroidism and hypothyroidism on glutamine metabolism by skeletal muscle of the rat. Biochem J. 1990 Dec 1;272(2):319–22.

68. Parry-Billings M, Dimitriadis GD, Leighton B, Dunger DB, Newsholme EA. The effects of growth hormone administration in vivo on skeletal muscle glutamine metabolism of the rat. Horm Metab Res Horm Stoffwechselforschung Horm Metab. 1993 Jun;25(6):292–3.

69. Cruzat VF, Keane KN, Scheinpflug AL, Cordeiro R, Soares MJ, Newsholme P. Alanyl-glutamine improves pancreatic ß-cell function following ex vivo inflammatory challenge. J Endocrinol. 2015 Mar;224(3):261–71.

70. Natural Medicines - Professional - Glutamine [Internet]. [cited 2021 Jun 9]. Available from: https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=878

71. Labow BI, Souba WW. Glutamine. World J Surg. 2000 Dec;24(12):1503–13.

72. Lenders C, Liu S, Wilmore D, Sampson L, Dougherty L, Spiegelman D, et al. Evaluation of a novel food composition database that includes glutamine and other amino acids derived from gene sequencing data. Eur J Clin Nutr. 2009 Dec;63(12):1433–9.

73. Huang X-X, Wang X-P, Ma J-J, Jing D-D, Wang P-W, Wu K. [Effects of enteral nutrition supplemented with glutamine and arginine on gut barrier in patients with severe acute pancreatitis: a prospective randomized controlled trial]. Zhonghua Yi Xue Za Zhi. 2008 Sep 9;88(34):2407–9.

74. Pugh JN, Sage S, Hutson M, Doran DA, Fleming SC, Highton J, et al. Glutamine supplementation reduces markers of intestinal permeability during running in the heat in a dose-dependent manner. Eur J Appl Physiol. 2017 Dec;117(12):2569–77.

75. Peng X, Yan H, You Z, Wang P, Wang S. Effects of enteral supplementation with glutamine granules on intestinal mucosal barrier function in severe burned patients. Burns J Int Soc Burn Inj. 2004 Mar;30(2):135–9.

76. Song H-Y, Jiang C-H, Yang J-R, Chen Q-H, Huang J, Huang Y-H, et al. [The change of intestinal mucosa barrier in chronic severe hepatitis B patients and clinical intervention]. Zhonghua Gan Zang Bing Za Zhi Zhonghua Ganzangbing Zazhi Chin J Hepatol. 2009 Oct;17(10):754–8.

77. Arutla M, Raghunath M, Deepika G, Jakkampudi A, Murthy HVV, Rao GV, et al. Efficacy of enteral glutamine supplementation in patients with severe andpredicted severe acute pancreatitis— Arandomized controlled trial. Indian J Gastroenterol. 2019 Aug 1;38(4):338–47.

78. Li Y, Yu Z, Liu F, Tan L, Wu B, Li J. Oral glutamine ameliorates chemotherapy-induced changes of intestinal permeability and does not interfere with the antitumor effect of chemotherapy in patients with breast cancer: a prospective randomized trial. Tumori. 2006 Oct;92(5):396–401.

79. Lima NL, Soares AM, Mota RMS, Monteiro HSA, Guerrant RL, Lima AAM. Wasting and intestinal barrier function in children taking alanyl-glutamine-supplemented enteral formula. J Pediatr Gastroenterol Nutr. 2007 Mar;44(3):365–74.

80. Conejero R, Bonet A, Grau T, Esteban A, Mesejo A, Montejo JC, et al. Effect of a glutamine-enriched enteral diet on intestinal permeability and infectious morbidity at 28 days in critically ill patients with systemic inflammatory response syndrome: a randomized, single-blind, prospective, multicenter study. Nutr Burbank Los Angel Cty Calif. 2002 Sep;18(9):716–21.

81. Velasco N, Hernandez G, Wainstein C, Castillo L, Maiz A, Lopez F, et al. Influence of polymeric enteral nutrition supplemented with different doses of glutamine on gut permeability in critically ill patients. Nutr Burbank Los Angel Cty Calif. 2001 Dec;17(11–12):907–11.

82. Chamorro S, de Blas C, Grant G, Badiola I, Menoyo D, Carabaño R. Effect of dietary supplementation with glutamine and a combination of glutamine-arginine on intestinal health in twenty-five-day-old weaned rabbits. J Anim Sci. 2010 Jan;88(1):170–80.

83. de Souza AZZ, Zambom AZ, Abboud KY, Reis SK, Tannihão F, Guadagnini D, et al. Oral supplementation with L-glutamine alters gut microbiota of obese and overweight adults: A pilot study. Nutr Burbank Los Angel Cty Calif. 2015 Jun;31(6):884–9.

84. Ley R, Turnbaugh P, Klein S, Gordon J. Microbial Ecology: Human gut microbes associated with obesity. Nature. 2007 Jan 1;444:1022–3.

85. Abboud KY, Reis SK, Martelli ME, Zordão OP, Tannihão F, de Souza AZZ, et al. Oral Glutamine Supplementation Reduces Obesity, Pro-Inflammatory Markers, and Improves Insulin Sensitivity in DIO Wistar Rats and Reduces Waist Circumference in Overweight and Obese Humans. Nutrients. 2019 Mar 1;11(3):536.

86. Manco M, Putignani L, Bottazzo GF. Gut microbiota, lipopolysaccharides, and innate immunity in the pathogenesis of obesity and cardiovascular risk. Endocr Rev. 2010 Dec;31(6):817–44.

87. Zhou Q, Verne ML, Fields JZ, Lefante JJ, Basra S, Salameh H, et al. Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome. Gut. 2019 Jun;68(6):996–1002.

88. Yalçin SS, Yurdakök K, Tezcan I, Oner L. Effect of glutamine supplementation on diarrhea, interleukin-8 and secretory immunoglobulin A in children with acute diarrhea. J Pediatr Gastroenterol Nutr. 2004 May;38(5):494–501.

89. Gutiérrez C, Villa S, Mota FR, Calva JJ. Does an L-glutamine-containing, glucose-free, oral rehydration solution reduce stool output and time to rehydrate in children with acute diarrhoea? A double-blind randomized clinical trial. J Health Popul Nutr. 2007 Sep;25(3):278–84.

90. Kamuchaki JM, Kiguli S, Wobudeya E, Bortolussi R. No benefit of glutamine supplementation on persistent diarrhea in Ugandan children. Pediatr Infect Dis J. 2013 May;32(5):573–6.

91. Sido B, Seel C, Hochlehnert A, Breitkreutz R, Dröge W. Low intestinal glutamine level and low glutaminase activity in Crohn’s disease: a rational for glutamine supplementation? Dig Dis Sci. 2006 Dec;51(12):2170–9.

92. Benjamin J, Makharia G, Ahuja V, Anand Rajan KD, Kalaivani M, Gupta SD, et al. Glutamine and whey protein improve intestinal permeability and morphology in patients with Crohn’s disease: a randomized controlled trial. Dig Dis Sci. 2012 Apr;57(4):1000–12.

93. Den Hond E, Hiele M, Peeters M, Ghoos Y, Rutgeerts P. Effect of long-term oral glutamine supplements on small intestinal permeability in patients with Crohn’s disease. JPEN J Parenter Enteral Nutr. 1999 Feb;23(1):7–11.

94. Akobeng AK, Elawad M, Gordon M. Glutamine for induction of remission in Crohn’s disease. Cochrane Database Syst Rev. 2016 Feb 8;2:CD007348.

95. Akobeng AK, Miller V, Thomas AG, Richmond K. Glutamine supplementation and intestinal permeability in Crohn’s disease. JPEN J Parenter Enteral Nutr. 2000 Jun;24(3):196.

96. Quan Z-F, Yang C, Li N, Li J-S. Effect of glutamine on change in early postoperative intestinal permeability and its relation to systemic inflammatory response. World J Gastroenterol. 2004 Jul 1;10(13):1992–4.

97. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, et al. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264–6.

98. Greenfield JR, Farooqi IS, Keogh JM, Henning E, Habib AM, Blackwood A, et al. Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects. Am J Clin Nutr. 2009 Jan;89(1):106–13.

99. Samocha-Bonet D, Wong O, Synnott E-L, Piyaratna N, Douglas A, Gribble FM, et al. Glutamine reduces postprandial glycemia and augments the glucagon-like peptide-1 response in type 2 diabetes patients. J Nutr. 2011 Jul;141(7):1233–8.

100. Song Q-H, Xu R-M, Zhang Q-H, Shen G-Q, Ma M, Zhao X-P, et al. Glutamine supplementation and immune function during heavy load training. Int J Clin Pharmacol Ther. 2015 May;53(5):372–6.

101. Legault Z, Bagnall N, Kimmerly DS. The Influence of Oral L-Glutamine Supplementation on Muscle Strength Recovery and Soreness Following Unilateral Knee Extension Eccentric Exercise. Int J Sport Nutr Exerc Metab. 2015 Oct;25(5):417–26.

102. Wilkinson SB, Kim PL, Armstrong D, Phillips SM. Addition of glutamine to essential amino acids and carbohydrate does not enhance anabolism in young human males following exercise. Appl Physiol Nutr Metab Physiol Appl Nutr Metab. 2006 Oct;31(5):518–29.

103. Valenzuela PL, Morales JS, Emanuele E, Pareja-Galeano H, Lucia A. Supplements with purported effects on muscle mass and strength. Eur J Nutr. 2019 Dec;58(8):2983–3008.

104. Antonio J, Sanders MS, Kalman D, Woodgate D, Street C. The effects of high-dose glutamine ingestion on weightlifting performance. J Strength Cond Res. 2002 Feb;16(1):157–60.

105. Candow DG, Chilibeck PD, Burke DG, Davison SK, Smith-Palmer T. Effect of glutamine supplementation combined with resistance training in young adults. Eur J Appl Physiol. 2001 Dec 1;86(2):142–9.

106. Bassini-Cameron A, Monteiro A, Gomes A, Werneck-de-Castro JPS, Cameron L. Glutamine protects against increases in blood ammonia in football players in an exercise intensity-dependent way. Br J Sports Med. 2008 Apr;42(4):260–6.

107. Sheard NF, Walker WA. The role of breast milk in the development of the gastrointestinal tract. Nutr Rev. 1988 Jan;46(1):1–8.

108. Burrin DG, Stoll B. Key nutrients and growth factors for the neonatal gastrointestinal tract. Clin Perinatol. 2002 Mar;29(1):65–96.

109. Sevastiadou S, Malamitsi-Puchner A, Costalos C, Skouroliakou M, Briana DD, Antsaklis A, et al. The impact of oral glutamine supplementation on the intestinal permeability and incidence of necrotizing enterocolitis/septicemia in premature neonates. J Matern-Fetal Neonatal Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet. 2011 Oct;24(10):1294–300.

110. Moe-Byrne T, Brown JVE, McGuire W. Glutamine supplementation to prevent morbidity and mortality in preterm infants. Cochrane Database Syst Rev. 2016 Apr 18;4:CD001457.

111. Williams EA, Elia M, Lunn PG. A double-blind, placebo-controlled, glutamine-supplementation trial in growth-faltering Gambian infants. Am J Clin Nutr. 2007 Aug;86(2):421–7.

112. Almeida EB, Santos JMB, Paixão V, Amaral JB, Foster R, Sperandio A, et al. L-Glutamine Supplementation Improves the Benefits of Combined-Exercise Training on Oral Redox Balance and Inflammatory Status in Elderly Individuals. Oxid Med Cell Longev. 2020;2020:2852181.

113. Amirato GR, Borges JO, Marques DL, Santos JMB, Santos CAF, Andrade MS, et al. L-Glutamine Supplementation Enhances Strength and Power of Knee Muscles and Improves Glycemia Control and Plasma Redox Balance in Exercising Elderly Women. Nutrients. 2021 Mar 22;13(3):1025.

114. Helling G, Wahlin S, Smedberg M, Pettersson L, Tjäder I, Norberg Å, et al. Plasma Glutamine Concentrations in Liver Failure. PloS One. 2016;11(3):e0150440.

115. Lemberg A, Alejandra Fernández M. Hepatic encephalopathy, ammonia, glutamate, glutamine and oxidative stress. Ann Hepatol. 2009 Apr 1;8(2):95–102.

116. Albrecht J, Norenberg MD. Glutamine: a Trojan horse in ammonia neurotoxicity. Hepatol Baltim Md. 2006 Oct;44(4):788–94.

117. Williams AN, Woessner KM. Monosodium glutamate “allergy”: menace or myth? Clin Exp Allergy J Br Soc Allergy Clin Immunol. 2009 May;39(5):640–6.

118. Jiang H, Liu C. [Protective effect of glutamine on intestinal barrier function in patients receiving chemotherapy]. Zhonghua Wei Chang Wai Ke Za Zhi Chin J Gastrointest Surg. 2006 Jan;9(1):59–61.

119. Garlick PJ. Assessment of the Safety of Glutamine and Other Amino Acids. J Nutr. 2001 Sep 1;131(9):2556S-2561S.

120. Galera SC, Fechine FV, Teixeira MJ, Coelho ZCB, de Vasconcelos RC, de Vasconcelos PRL. The safety of oral use of L-glutamine in middle-aged and elderly individuals. Nutr Burbank Los Angel Cty Calif. 2010 Apr;26(4):375–81.

121. Ogden HB, Child RB, Fallowfield JL, Delves SK, Westwood CS, Millyard A, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020 Sep 27;12(10):E2953.

122. Finamore A, Massimi M, Conti Devirgiliis L, Mengheri E. Zinc deficiency induces membrane barrier damage and increases neutrophil transmigration in Caco-2 cells. J Nutr. 2008 Sep;138(9):1664–70.

123. Skrovanek S, DiGuilio K, Bailey R, Huntington W, Urbas R, Mayilvaganan B, et al. Zinc and gastrointestinal disease. World J Gastrointest Pathophysiol. 2014 Nov 15;5(4):496–513.

124. Sturniolo GC, Di Leo V, Ferronato A, D’Odorico A, D’Incà R. Zinc supplementation tightens “leaky gut” in Crohn’s disease. Inflamm Bowel Dis. 2001 May;7(2):94–8.

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